The aim of this study was to measure neutrophil function longitudinally following burn injury and to examine the relationship between neutrophil dysfunction and sepsis.
Sepsis is especially dangerous in patients with extreme burn injuries and can be hard to spot due to the inflammatory response occurring in burns patients. This cohort study tracked 150 patients with serious burns to more than 15% of their body over the period of a year.
Published in Annals of Surgery, this study found that neutrophil function, immature granulocytes count and plasma cell free DNA levels show potential as biomarkers for the prediction or early diagnosis of sepsis post-burn injury. Neutrophil dysfunction may also actively contribute to the development of sepsis. This means that targeting neutrophil dysfunction and IG release may be a viable therapeutic intervention to help reduce the incidence of nosocomial infections and sepsis post-burn.