Gene clue to renal transplant failure

01 December 2012

Dr Richard Borrows

Dr Richard Borrows

A single gene could harbour part of the secretas to why more than half of transplanted kidneys fail within 10 years, a new QEHB-led study has found.

The study of 4,471 European transplant recipients, some of whom were followed for20 years, was led by nephrology consultant Dr Richard Borrows.

Its findings were published in the Journal of the American Society ofNephrologists.

It found that kidneys with one version of the ABCB1 gene were 69 percent more likely to fail, sending patients back to dialysis and the transplant waiting list.

The study, which was published in the Journal of the American Society of Nephrology,did not investigate the mechanism behind his finding, but called for further research.

It is known that the protein encoded bythis gene (p-glycoprotein) is involved in the handling of immunosuppressive drugs whichmay accumulate in the kidney and causedamage.

However, there are a number of other possibilities which warrant future study.

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