Every year, it is estimated that there are 13 million cases of typhoid and paratyphoid A fever combined, resulting in 133 thousand deaths, mainly affecting school-aged children in Asia and Africa.  

We are looking for healthy volunteers to take part in a study to test a new vaccine against typhoid and paratyphoid A fever. 

In order to test if the vaccine works to protect against paratyphoid A fever, after vaccination with the new vaccine or a control vaccine, we will be challenging all participants with the bacteria that could cause paratyphoid fever. Participants will be treated with antibiotics as soon as they show symptoms of infection, or 14 days after drinking the bacteria even if they don’t have symptoms. 

The study is being run by University Hospitals Birmingham NHS Foundation Trust (UHB) in collaboration with the Oxford Vaccine Group and is funded by the Serum Institute of India. 

If you are aged 18 to 55 years old, and in good health, you may be eligible to take part in the study. You will be provided with reimbursement for your time, inconvenience, and travel. 

Participants will receive up to £4410 if they remain in the study for the entire period and attend all the scheduled visits required for them. 

The total study participation time is seven months. During this time, you will be required to attend the Queen Elizabeth Hospital Birmingham (part of UHB) for all study visits and the Oxford Vaccine Group on challenge administration day (travel will be arranged if applicable). 

If you are interested in finding out more, please visit https://www.ovg.ox.ac.uk/studies/bivista/birmingham where you can access the Participant Information Sheet. 

If you would like any further information regarding the study, please contact us on: Email BiVISTA@uhb.nhs.uk, Tel: 0121 371 1378