Expression and function of immune regulatory proteins in human liver

Research Summary

The liver has a unique ability to tolerate potentially damaging inflammatory immune responses but the mechanisms responsible are not known. This allows the liver to escape damaging responses to for example food antigens whilst mounting effective responses to most infections. To counteract infections white blood cells are recruited from the blood into the liver and these cells then determine whether an antigen is ignored or whether it is attacked by the immune response. If this process becomes dysregulated chronic inflammation can be triggered leading to persistent inflammation scarring and cirrhosis. This pathway is responsible for most of the common liver diseases inicuding those stimulated by alcohol fat viral infection and autoimmunity. The aim of our work is to determine the molecular regulation of this dysregulated inflammation using human tissues to understand disease pathogenesis and develop novel anti—inflammatory therapies. Understanding these process will elucidate the pathogenesis of liver disease and may suggest novel ways to treat inflammatory liver disease by switching off or modulating signals that activate inflamation and tissue damage in the liver.

Research Overview
PI Name Adams - DH
Sponsor University of Birmingham
Project Status Open
Proposed End Date 30/08/2019
Study Run through CRF? No
Recruitment so far 0