Measurement of the Central Respiratory Rhythm in Healthy Volunteers

Research Summary

The control of breathing in Man has been the subject of considerable investigation but despite this much of the detailed central control mechanisms in humans remains poorly understood because of the difficulty of measuring their central respiratory rhythm directly. Abnormalities of central control are of clinical importance in conditions ranging from sudden infant death syndrome and sleep apnoea to the effects of anaesthetic and analgesic drugs. Abnormalities of respiratory control are also common in ventilated intensive care patients and may lead to considerable delay in weaning from mechanical ventilation.Successful discovery of means of more direct measurement of the central respiratory rhythm using a range of simple and non—invasive tests in normal volunteers will enhance our understanding of the control of the central respiratory rhythm. We would hope to progress to preparing new means of measuring the central respiratory rhythm in intensive care patients that would improve their comfort and well being during mechanical ventilation and improve their successful weaning from mechanical ventilation.A secondary area of considerable importance is the early detection of coronary heart disease and impairment of cerebral function with age and disease. Inducing hypocapnia is our principle means of attenuating and hence investigating the central respiratory rhythm. This hypocapnia also produces changes in heart and brain function that could enhance the early detection of coronary heart disease and impaired cerebral function. Our secondary research objective therefore is to measure the effects of hypocapnia on heart and brain function in normal volunteers to assess their potential clinical importance in the diagnosis of myocardial and cerebral ischaemia.

Research Overview
PI Name Clutton-Brock - TH
Sponsor University of Birmingham
Project Status Open
Proposed End Date 30/11/2021
Study Run through CRF? Yes
Recruitment so far 55