Research Study into the genetic causes of PSC
A UK Collaborative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC)
PSC is a condition in which the bile ducts of the liver become inflammed & destroyed. Patients with this condition may be either symptomatic or asymptomatice on presentation. Symptoms of the disease include itch jaundice and fatigue. With the progression of liver disease & the development of cirrhosis (scarring of the liver) patients may suffer complications & ultimately require a liver transplant. In addition patients with this condition are predisposed to develop cancer of either the bile ducts gallbladder pancreas & the colon.There is epidemiological data to suggest that genetic factors are important in the development of PSC. PSC is more common in people that have a close relative with the condition.We propose that by peforming a genome association scan from a cohort of patients with PSC we will potentially identify new genetic determinants that contribute to this disease which may lead to better treatments & animal models of PSC.
|Sponsor||Cambridge University Hospitals NHS Foundation Trust|
|Proposed End Date||01/07/2023|
|Study Run through CRF?||No|
|Recruitment so far||38|