Bence Jones Antigen Collection from Urine
Paraprotein assays (e.g. serum Freelite chain assays) are blood tests used to diagnose disease type and to measure and monitor the paraprotein status of patients with monoclonal gammopathies. Clinicians use this information as an aid to diagnosis and as a guide in the treatment and management of the patient. The availability of Bence Jonesprotein antigens is essential for the manufacture of these assays. These proteins cannot be manufactured artificially and therefore have to be sourced from patient volunteers. It would be impossible to undertake research on new assays validate existing assays or manufacture assays without them.Patients that are likely to have greater than 1g/L of kappa or lambda paraproteins (Bence Jones proteins) in their urine will be approached by their treating physician under the guidance of the head of the myeloma renal clinic. If the patient is willing to donate their urine they will be provided with a suitable container (labeled with their date of birth and initials). They will be asked to collect their urine for the preceding 24 hours before their next appointment and then to bring this along with them to their appointment. The patient will be compensated for any inconvenience and also reimbursed for any additional traveling expenses incurred. The urine will be processed to purify the Bence Jones proteins. All cellular material will be removed and appropriately disposed of no DNA will remain in the sample and the purified proteins will be anonymised.
|PI Name||Cook - MA|
|Proposed End Date||01/10/2014|
|Study Run through CRF?||No|
|Recruitment so far||0|