Survey of the prevalence of abnormal PrP using archived appendix tissue in the English population

Research Summary

A collection of 30000 stored appendix samples will be retrieved from the archives of participating histopathology departments of hospitals throughout the UK. These samples will be unlinked and irreversibly anonymised and tested by immunohistochemistry (IHC) for the presence of abnormal prion protein. This should enable discepancies betweenthe current estimates for the prevalence of subclinical vCJD infection to be resolved.

Research Overview
PI Name Moore - J
Sponsor Health Protection Agency
Project Status Open
Proposed End Date 31/01/2012
Study Run through CRF? No
Recruitment so far 0