Delirium in hospital of undiagnosed dementia

Delirium in General Hospital as a marker of Undiagnosed Dementia: Evaluation of Pragmatic Methods for Screening and Follow-up

Research Summary

Dementia is common in older inpatients but only half will have a previous diagnosis of dementia. Delirium is a common severe inpatient acute neuropsychiatric syndrome. Two-thirds of cases of delirium occur in patients with dementia. Delirium therefore provides an opportunity to identify undiagnosed dementia. However because delirium affects cognition detecting dementia is problematic. Aims:To determine if in older hospital inpatients with delirium: (1) There is dementia (2) Simple informant questionnaires can identify dementia To determine if key clinical factors routine blood tests or putative endocrine or immune biomarkers predict poorer outcomes in patients with delirium.Methods230 patients aged over 70 years with delirium will be assessed through detailed carer interview for the presence pre-existing DSM-IV dementia (gold standard). This will be compared with (blinded) assessments of dementia using simple clinically pragmatic informant questionnaires. Key clinical variables and putative prognostic endocrine and immune indicators of prognosis will be measured. Participants will undergo a home visit at 3 months to confirm presence/absence of dementia. Expected OutcomesValidation of informant questionnaires for detection of dementia in delirium will provide a pragmatic method of detecting undiagnosed dementia in general hospitals potentially benefiting tens of thousands of patients in the UK per year.

Research Overview
PI Name Jackson - T
Sponsor University of Birmingham
Project Status Open
Proposed End Date 01/04/2015
Study Run through CRF? No
Target number of patients agreed to recruit 240
Recruitment so far 0